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Case Report

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  • Case Reports

An article that describes and interprets an individual case, often written in the form of a detailed story. Case reports often describe:

  • Unique cases that cannot be explained by known diseases or syndromes
  • Cases that show an important variation of a disease or condition
  • Cases that show unexpected events that may yield new or useful information
  • Cases in which one patient has two or more unexpected diseases or disorders

Case reports are considered the lowest level of evidence, but they are also the first line of evidence, because they are where new issues and ideas emerge. This is why they form the base of our pyramid. A good case report will be clear about the importance of the observation being reported.

If multiple case reports show something similar, the next step might be a case-control study to determine if there is a relationship between the relevant variables.

  • Can help in the identification of new trends or diseases
  • Can help detect new drug side effects and potential uses (adverse or beneficial)
  • Educational – a way of sharing lessons learned
  • Identifies rare manifestations of a disease

Disadvantages

  • Cases may not be generalizable
  • Not based on systematic studies
  • Causes or associations may have other explanations
  • Can be seen as emphasizing the bizarre or focusing on misleading elements

Design pitfalls to look out for

The patient should be described in detail, allowing others to identify patients with similar characteristics.

Does the case report provide information about the patient's age, sex, ethnicity, race, employment status, social situation, medical history, diagnosis, prognosis, previous treatments, past and current diagnostic test results, medications, psychological tests, clinical and functional assessments, and current intervention?

Case reports should include carefully recorded, unbiased observations.

Does the case report include measurements and/or recorded observations of the case? Does it show a bias?

Case reports should explore and infer, not confirm, deduce, or prove. They cannot demonstrate causality or argue for the adoption of a new treatment approach.

Does the case report present a hypothesis that can be confirmed by another type of study?

Fictitious Example

A physician treated a young and otherwise healthy patient who came to her office reporting numbness all over her body. The physician could not determine any reason for this numbness and had never seen anything like it. After taking an extensive history the physician discovered that the patient had recently been to the beach for a vacation and had used a very new type of spray sunscreen. The patient had stored the sunscreen in her cooler at the beach because she liked the feel of the cool spray in the hot sun. The physician suspected that the spray sunscreen had undergone a chemical reaction from the coldness which caused the numbness. She also suspected that because this is a new type of sunscreen other physicians may soon be seeing patients with this numbness.

The physician wrote up a case report describing how the numbness presented, how and why she concluded it was the spray sunscreen, and how she treated the patient. Later, when other doctors began seeing patients with this numbness, they found this case report helpful as a starting point in treating their patients.

Real-life Examples

Hymes KB. Cheung T. Greene JB. Prose NS. Marcus A. Ballard H. William DC. Laubenstein LJ. (1981). Kaposi's sarcoma in homosexual men-a report of eight cases. Lancet. 2(8247), 598-600.

This case report was published by eight physicians in New York city who had unexpectedly seen eight male patients with Kaposi’s sarcoma (KS). Prior to this, KS was very rare in the U.S. and occurred primarily in the lower extremities of older patients. These cases were decades younger, had generalized KS, and a much lower rate of survival. This was before the discovery of HIV or the use of the term AIDS and this case report was one of the first published items about AIDS patients.

Wu, E. B., & Sung, J. J. Y. (2003). Haemorrhagic-fever-like changes and normal chest radiograph in a doctor with SARS. Lancet, 361(9368), 1520-1521.

This case report is written by the patient, a physician who contracted SARS, and his colleague who treated him, during the 2003 outbreak of SARS in Hong Kong. They describe how the disease progressed in Dr. Wu and based on Dr. Wu’s case, advised that a chest CT showed hidden pneumonic changes and facilitate a rapid diagnosis.

Related Terms

Case Series

A report about a small group of similar cases.

Preplanned Case-Observation

A case in which symptoms are elicited to study disease mechanisms. (Ex. Having a patient sleep in a lab to do brain imaging for a sleep disorder).

Now test yourself!

1. Case studies are not considered evidence-based even though the authors have studied the case in great depth.

a) True b) False

2. When are Case reports most useful?

a) When you encounter common cases and need more information b) When new symptoms or outcomes are unidentified c) When developing practice guidelines d) When the population being studied is very large

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Quantitative study designs: Case Studies/ Case Report/ Case Series

Quantitative study designs.

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Case Study / Case Report / Case Series

Some famous examples of case studies are John Martin Marlow’s case study on Phineas Gage (the man who had a railway spike through his head) and Sigmund Freud’s case studies, Little Hans and The Rat Man. Case studies are widely used in psychology to provide insight into unusual conditions.

A case study, also known as a case report, is an in depth or intensive study of a single individual or specific group, while a case series is a grouping of similar case studies / case reports together.

A case study / case report can be used in the following instances:

  • where there is atypical or abnormal behaviour or development
  • an unexplained outcome to treatment
  • an emerging disease or condition

The stages of a Case Study / Case Report / Case Series

case series study disadvantages

Which clinical questions does Case Study / Case Report / Case Series best answer?

Emerging conditions, adverse reactions to treatments, atypical / abnormal behaviour, new programs or methods of treatment – all of these can be answered with case studies /case reports / case series. They are generally descriptive studies based on qualitative data e.g. observations, interviews, questionnaires, diaries, personal notes or clinical notes.

What are the advantages and disadvantages to consider when using Case Studies/ Case Reports and Case Series ?

What are the pitfalls to look for.

One pitfall that has occurred in some case studies is where two common conditions/treatments have been linked together with no comprehensive data backing up the conclusion. A hypothetical example could be where high rates of the common cold were associated with suicide when the cohort also suffered from depression.

Critical appraisal tools 

To assist with critically appraising Case studies / Case reports / Case series there are some tools / checklists you can use.

JBI Critical Appraisal Checklist for Case Series

JBI Critical Appraisal Checklist for Case Reports

Real World Examples

Some Psychology case study / case report / case series examples

Capp, G. (2015). Our community, our schools : A case study of program design for school-based mental health services. Children & Schools, 37(4), 241–248. A pilot program to improve school based mental health services was instigated in one elementary school and one middle / high school. The case study followed the program from development through to implementation, documenting each step of the process.

Cowdrey, F. A. & Walz, L. (2015). Exposure therapy for fear of spiders in an adult with learning disabilities: A case report. British Journal of Learning Disabilities, 43(1), 75–82. One person was studied who had completed a pre- intervention and post- intervention questionnaire. From the results of this data the exposure therapy intervention was found to be effective in reducing the phobia. This case report highlighted a therapy that could be used to assist people with learning disabilities who also suffered from phobias.

Li, H. X., He, L., Zhang, C. C., Eisinger, R., Pan, Y. X., Wang, T., . . . Li, D. Y. (2019). Deep brain stimulation in post‐traumatic dystonia: A case series study. CNS Neuroscience & Therapeutics. 1-8. Five patients were included in the case series, all with the same condition. They all received deep brain stimulation but not in the same area of the brain. Baseline and last follow up visit were assessed with the same rating scale.

References and Further Reading  

Greenhalgh, T. (2014). How to read a paper: the basics of evidence-based medicine. (5th ed.). New York: Wiley.

Heale, R. & Twycross, A. (2018). What is a case study? Evidence Based Nursing, 21(1), 7-8.

Himmelfarb Health Sciences Library. (2019). Study design 101: case report. Retrieved from https://himmelfarb.gwu.edu/tutorials/studydesign101/casereports.cfm

Hoffmann T., Bennett S., Mar C. D. (2017). Evidence-based practice across the health professions. Chatswood, NSW: Elsevier.

Robinson, O. C., & McAdams, D. P. (2015). Four functional roles for case studies in emerging adulthood research. Emerging Adulthood, 3(6), 413-420.

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  • Last Updated: Jan 17, 2024 11:49 AM
  • URL: https://deakin.libguides.com/quantitative-study-designs
  • Research article
  • Open access
  • Published: 23 April 2014

The clinical case report: a review of its merits and limitations

  • Trygve Nissen 1 , 2 &
  • Rolf Wynn 1 , 3  

BMC Research Notes volume  7 , Article number:  264 ( 2014 ) Cite this article

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The clinical case report has a long-standing tradition in the medical literature. While its scientific significance has become smaller as more advanced research methods have gained ground, case reports are still presented in many medical journals. Some scholars point to its limited value for medical progress, while others assert that the genre is undervalued. We aimed to present the various points of view regarding the merits and limitations of the case report genre. We searched Google Scholar, PubMed and select textbooks on epidemiology and medical research for articles and book-chapters discussing the merits and limitations of clinical case reports and case series.

The major merits of case reporting were these: Detecting novelties, generating hypotheses, pharmacovigilance, high applicability when other research designs are not possible to carry out, allowing emphasis on the narrative aspect (in-depth understanding), and educational value. The major limitations were: Lack of ability to generalize, no possibility to establish cause-effect relationship, danger of over-interpretation, publication bias, retrospective design, and distraction of reader when focusing on the unusual.

Conclusions

Despite having lost its central role in medical literature in the 20th century, the genre still appears popular. It is a valuable part of the various research methods, especially since it complements other approaches. Furthermore, it also contributes in areas of medicine that are not specifically research-related, e.g. as an educational tool. Revision of the case report genre has been attempted in order to integrate the biomedical model with the narrative approach, but without significant success. The future prospects of the case report could possibly be in new applications of the genre, i.e. exclusive case report databases available online, and open access for clinicians and researchers.

Throughout history the clinical case report and case report series have been integral components of medical literature[ 1 ]. The case report genre held a strong position until it was sidelined in the second half of the 20 th century[ 2 , 3 ]. New methodologies for research articles paved the way for evidence-based medicine. Editors had to make space for these research articles and at the same time signaled less enthusiasm for publishing case reports[ 4 ]. This spurred some heated debates in medical journals as readers were worried that the traditional case report was in jeopardy[ 5 , 6 ]. Those who welcomed the new trend with fewer case reports being published pointed mainly to their low quality and inclination to emphasize mere curiosa[ 7 – 9 ]. Some of the proponents of the genre claimed that the case report had been and still was indispensible for furthering medical knowledge and that it was unique in taking care of the detailed study of the individual patient as opposed to the new research methods with their “…nomothetic approach [taking] precedence…”[ 5 ]. Still, the case report got a low ranking on the evidence hierarchy. After a decline in popularity a new interest for the case report emerged, probably beginning in the late 1990s[ 2 ]. A peer-reviewed ‘Case reports’ section was introduced in the Lancet in 1995[ 10 ]. In 2007, the first international, Pubmed-listed medical journal publishing only case reports was established[ 11 , 12 ]. In the following years, several similar journals, for the most part online and open-access, have been launched.

The present debate is not so much focused on whether case reporting is obsolete or not. Some of the discussions after the turn of the century have been about adapting the case report genre to new challenges. One example is the suggestion of incorporating the narrative, i.e. “… stressing the patient’s story”, in the case report[ 13 ]. The authors termed their initiative “The storied case report”. Their endeavor was not met with success. In analyzing the causes for this, they wondered if “… junior trainees find it too hard to determine what is relevant and senior trainees find it too hard to change their habits”[ 13 ]. A similar attempt was done when the editors of the Journal of Medical Case Reports in 2012 encouraged authors to include the patients’ perspectives by letting patients describe their own experiences[ 14 ].

Notwithstanding, we feel there is much to be gained from having an ongoing discussion highlighting the indications and contraindications for producing case reports. This can to some degree be facilitated by getting an understanding of the merits and limitations of the genre. The objective of this article is to present the merits and limitations of case reports and case series reports.

We adopted Taber’s Cyclopedic Medical Dictionary’s definition of the case report : “A formal summary of a unique patient and his or her illness, including the presenting signs and symptoms, diagnostic studies, treatment course and outcome”[ 15 ]. A case report consists of one or two cases, most often only one. The case series or case series report usually consists of three to ten cases[ 16 ]. (In the following we use the term case report to denote both case reports and case series report). Case reports are most often naturalistic and descriptive. Sometimes, however, they can be prospective and experimental.

As literature specifically dealing with the case report genre seemed harder to elicit from the databases than the vast amount of particular case reports, we performed iterative searches. We searched Google Scholar and PubMed using the search terms ‘case report(s)’, ‘case series’, ‘case series report(s)’, ‘case reporting’ in various combinations with ‘clinical’, ‘medical’, ‘anecdotal’, ‘methodology’, ‘review’, ‘overview’, ‘strengths’, ‘weaknesses’, ‘merits’, and ‘limitations’. Further references were identified by examining the literature found in the electronic searches. We also consulted major textbooks on epidemiology[ 17 , 18 ], some scholars of medical genres[ 19 , 20 ] and a monograph on case reporting by the epidemiologist M. Jenicek[ 16 ]. We delimited our review to the retrospective, naturalistic, and descriptive case report, also labeled the “traditional” or “classic” case report, and case series including such reports. Thus we excluded other types, such as the planned, qualitative case study approach[ 21 ] and simulated cases[ 22 – 24 ]. Finally, we extracted the relevant data and grouped the merits and limitations items in rank order with the items we judged to be the most important first.

New observations

The major advantage of case reporting is probably its ability to detect novelties[ 16 ]. It is the only way to present unusual, uncontrolled observations regarding symptoms, clinical findings, course of illness, complications of interventions, associations of diseases, side effects of drugs, etc. In short, anything that is rare or has never been observed previously might be important for the medical community and ought to be published. A case report might sensitize readers and thus facilitate detection of similar or identical cases.

Generating hypotheses

From a single, or preferably several single case reports or a case series, new hypotheses could be formulated. These could then be tested with formal research methods that are designed to refute or confirm the hypotheses, i.e. comparative (observational and experimental) studies.

There are numerous examples of new discoveries or major advancements in medicine that started with a case report or, in some cases, as humbly as a letter to the editor. The first concern from the medical community about the devastating side effect of thalidomide, i.e. the congenital abnormalities, appeared as a letter to the editor in the Lancet in 1961[ 25 ]. Soon thereafter, several case reports and case series reports were published in various journals. Case reporting is thus indispensable in drug safety surveillance (pharmacovigilance)[ 26 ].

Sometimes significant advancements in knowledge have come not from what researchers were pursuing, but from “accidental discoveries”, i.e. by serendipity. The story of Alexander Fleming’s discovery of penicillin in 1928 is well known in the medical field[ 27 ]. Psychiatry has profited to a large degree from this mode of advancing medical science as many of the drugs used for mental disorders have been discovered serendipitously[ 27 ]. One notable example is the discovery of the effect of lithium on manic episodes in patients with manic-depressive disorder[ 28 ]. A more recent discovery is the successful treatment of infantile hemangiomas with systemic propranolol. This discovery was published, as a case series report, in the correspondence section in New England Journal of Medicine [ 29 ]. However, the evidence for the effect of this treatment is still preliminary, and several randomized trials are under way[ 30 , 31 ].

Clear and operational entities are prerequisites for doing medical research. Descriptions must come before understanding. Clinical observations that lead to new disorders being described are well suited for case reporting. The medical literature is replete with case-based articles describing new diseases and syndromes. One notable example is the first description of neurasthenia by G. Beard in Boston Medical and Surgical Journal in 1869[ 32 ].

Researching rare disorders

For rare disorders randomized controlled trials (RCTs) can be impossible to run due to lack of patients to be enrolled. Research on drug treatment and other kinds of interventions must therefore be based on less rigorous methodologies, among them case series and case reports. This would be in accordance with the European Commission’s recommendation to its members to improve health care for those with rare disorders[ 33 ].

Solving ethical constraints

Case reporting can be valuable when ethical constraints prohibit experimental research. Take as an example the challenge of how to manage the side effects of accidental extravasation of cytotoxic drugs. As RCTs on humans seem unethical in this clinical situation the current guidelines rest on small observational studies, case reports and animal studies[ 34 ]. Or another example: Physical restraint is sometimes associated with sudden, unexpected death. The cause or causes for this are to some degree enigmatic, and it is hard to conceive of a controlled study that could be ethical[ 35 , 36 ]. Case reports and case series being “natural experiments” might be the only evidence available for guiding clinical practice.

In-depth narrative case studies

Case reporting can be a way of presenting research with an idiographic emphasis. As contrasted to nomothetic research, an idiographic approach aims at in-depth understanding of human phenomena, especially in the field of psychology and psychiatry. The objective is not generalizable knowledge, but an understanding of meaning and intentionality for an individual or individuals. Sigmund Freud’s case studies are relevant examples. This usage of case reports borders on qualitative research. Qualitative studies, although developed in the social sciences, have become a welcome contribution within health sciences in the last two decades.

Educational value

Clinical medical learning is to a large degree case-based. Typical case histories and vignettes are often presented in textbooks, in lectures, etc. Unusual observations presented as published case reports are important as part of doctors’ continuing medical education, especially as they demonstrate the diversity of manifestations both within and between medical diseases and syndromes[ 37 , 38 ]. Among the various medical texts, the case report is the only one that presents day-to-day clinical practice, clinicians’ diagnostic reasoning, disease management, and follow-up. We believe that some case reports that are written with the aim of contributing to medical knowledge turn out to be of most value educationally because the phenomena have already been described elsewhere. Other case reports are clearly primarily written for educational value[ 37 ]. Some journals have regular sections dedicated to educational case reports, e.g. The Case Records of the Massachusetts General Hospital in the New England Journal of Medicine and the Clinical Case Conference found in the American Journal of Psychiatry.

The cost of doing a case report is low compared to planned, formal studies. Most often the necessary work is probably done in the clinical setting without specific funding. Larger studies, for instance RCTs, will usually need an academic setting.

Fast publication

The time span from observation to publication can be much shorter than for other kinds of studies. This is obviously a great advantage as a case report can be an important alert to the medical community about a serious event. The unexpected side effects of the sedative-antinauseant thalidomide on newborn babies is a telling story. The drug had been prescribed during pregnancy to the babies’ mothers. After the first published observation of severe abnormalities in babies appeared as a letter to the editor of the Lancet in December 16 th , 1961[ 25 ], several case reports and series followed[ 39 , 40 ]. It should be mentioned though that the drug company had announced on December 2 nd , 1961, i.e. two weeks before the letter from McBride[ 25 ], that it would withdraw the drug form the market immediately[ 41 ].

Flexible structure

Riaz Agha, editor of the International Journal of Surgery Case Reports suggests that the case report, with its less rigid structure is useful as it “… allows the surgeon(s) to discuss their diagnostic approach, the context, background, decision-making, reasoning and outcomes”[ 42 ]. Although the editor is commenting on the surgical case report, the argument can be applied for the whole field of clinical medicine. It should be mentioned though, that other commentators have argued for a more standardized, in effect more rigid, structure[ 43 ].

Clinical practice can be changed

Case reporting can lead to or contribute to a change in clinical practice. A drug might be withdrawn from the market. Or a relabeling might change the attitude to and treatment of a condition. During Word War I the shell shock syndrome was labeled and described thoroughly in several articles in the Lancet , the first of them appearing in February 1915[ 44 ]. The author was the British captain and military doctor Charles S. Myers. Before his efforts to bring good care and treatment to afflicted soldiers there had been a common misconception that many of these dysfunctional soldiers were malingerers or cowards.

Exercise for novice researchers

The case report format is well suited for young doctors not yet trained as researchers. It can be an opportunity for a first exercise in authoring an article and a preparation for a scientific career[ 37 , 45 , 46 ].

Communication between the clinical and academic fields

Articles authored by clinicians can promote communication between practicing clinicians and academic researchers. Observations published can generate ideas and be a trigger for further studies. For instance, a case series consisting of several similar cases in a short period can make up the case-group for a case–control study[ 47 ]. Clinicians could do the observation and publish the case series while the case–control study could be left to the academics.

Entertainment

Some commentators find reading case reports fun. Although a rather weak argument in favor of case reporting, the value of being entertained should not be dismissed altogether. It might inspire physicians to spend more time browsing and reading scientific literature[ 48 ].

Studying the history of medicine

Finally, we present a note on a different and unintended aspect of the genre. The accumulated case reports from past eras are a rich resource for researching and understanding medical history[ 49 , 50 ]. A close study of old case reports can provide valuable information about how medicine has been practiced through the centuries[ 50 , 51 ].

  • Limitations

No epidemiological quantities

As case reports are not chosen from representative population samples they cannot generate information on rates, ratios, incidences or prevalences. The case or cases being the numerator in the equation, has no denominator. However, if a case series report consists of a cluster of cases, it can signal an important and possibly causal association, e.g. an epidemic or a side effect of a newly marketed drug.

Causal inference not possible

Causality cannot be inferred from an uncontrolled observation. An association does not imply a cause-effect relationship. The observation or event in question could be a mere coincidence. This is a limitation shared by all the descriptive studies[ 47 ]. Take the thalidomide tragedy already mentioned as an example; Unusual events such as congenital malformations in some of the children born to mothers having taken a specific drug during pregnancy does not prove that the drug is the culprit. It is a mere hypothesis until further studies have either rejected or confirmed it. Cause-effect relationships require planned studies including control groups that to the extent possible control for chance, bias and confounders[ 52 ].

Generalization not possible

From the argument above, it follows that findings from case reports cannot be generalized. In order to generalize we need both a cause-effect relationship and a representative population for which the findings are valid. A single case report has neither. A case series, on the other hand, e.g. many “thalidomide babies” in a short time period, could strengthen the suspicion of a causal relationship, demanding further surveillance and research.

Publication bias could be a limiting factor. Journals in general favor positive-outcome findings[ 53 ]. One group of investigators studying case reports published in the Lancet found that only 5% of case reports and 10% of case series reported treatment failures[ 54 ]. A study of 435 case reports from the field of dentistry found that in 99.1%, the reports “…clearly [had] a positive outcome and the intervention was considered and described as successful by the authors”[ 55 ].

Overinterpretation

Overinterpretation or misinterpretation is the tendency or temptation to generalize when there is no justification for it. It has also been labeled “the anecdotal fallacy”[ 56 ]. This is not a shortcoming intrinsic to the method itself. Overinterpretation may be due to the phenomenon of case reports often having an emotional appeal on readers. The story implicitly makes a claim to truth. The reader might conclude prematurely that there is a causal connection. The phenomenon might be more clearly illustrated by the impact of the clinician’s load of personal cases on his or her practice. Here exemplified by a young doctor’s confession: “I often tell residents and medical students, ‘The only thing that actually changes practice is adverse anecdote.’”[ 57 ].

Emphasis on the rare

As case reporting often deals with the rare and atypical, it might divert the readers’ attention from common diseases and problems[ 58 ].

Confidentiality

Journals today require written informed consent from patients before publishing case reports. Both authors and publishers are responsible for securing confidentiality. A guarantee for full confidentiality is not always possible. Despite all possible measures taken to preserve confidentiality, sometimes the patient will be recognized by someone. This information should be given to the patient. An adequately informed patient might not consent to publication. In 1995 in an Editorial in the British Journal of Psychiatry one commentator, Isaac Marks, feared that written consent would discourage case reports being written[ 59 ]. Fortunately, judged form the large number of reports being published today, it seems unlikely that the demand for consent has impeded their publication.

Other methodological limitations

Case reports and series are written after the relevant event, i.e. the observation. Thus, the reports are produced retrospectively. The medical record might not contain all relevant data. Recall bias might prevent us from getting the necessary information from the patient or other informants such as family members and health professionals.

It has also been held against case reporting that it is subjective. The observer’s subjectivity might bias the quality and interpretation of the observation (i.e. information bias).

Finally, the falsification criterion within science, which is tested by repeating an experiment, cannot be applied for case reports. We cannot design another identical and uncontrolled observation. However, unplanned similar “experiments” of nature can be repeated. Several such observations can constitute a case series that represents stronger indicative evidence than the single case report.

The major advantages of case reporting are the ability to make new observations, generate hypotheses, accumulate scientific data about rare disorders, do in-depth narrative studies, and serve as a major educational tool. The method is deficient mainly in being unable to deliver quantitative data. Nor can it prove cause-effect relationship or allow generalizations. Furthermore, there is a risk of overinterpretation and publication bias.

The traditional case report does not fit easily into the qualitative-quantitative dichotomy of research methods. It certainly shares some characteristics with qualitative research[ 16 ], especially with regard to the idiographic, narrative perspective – the patient’s “interior world”[ 60 ] – that sometimes is attended to. Apart from “The storied case report” mentioned in the Background-section, other innovative modifications of the traditional case report have been tried: the “evidence-based case report”[ 61 ], the “interactive case report”[ 62 ] and the “integrated narrative and evidence based case report”[ 63 ]. These modifications of the format have not made a lasting impact on the way case reports in general are written today.

The method of case reporting is briefly dealt with in some textbooks on epidemiology[ 17 , 18 ]. Journals that welcome case reports often put more emphasis on style and design than on content in their ‘instruction to authors’ section[ 64 ]. As a consequence, Sorinola and coworkers argue for more consensus and more consistent guidance on writing case reports[ 64 ]. We feel that a satisfactory amount of guidance concerning both style and content now exists[ 12 , 16 , 65 , 66 ]. The latest contribution, “The CARE guidelines”, is an ambitious endeavor to improve completeness and transparency of reports[ 66 ]. These guidelines have included the “Patient perspective” as an item, apparently a bit half-heartedly as this item is placed after the Discussion section, thus not allowing this perspective to influence the Discussion and/or Conclusion section. We assume this is symptomatic of medicine’s problem with integrating the biomedical model with “narrative-based medicine”.

In recent years the medical community has taken an increased interest in case reports[ 2 ], especially after the surge of online, exclusive case report journals started in 2007 with the Journal of Medical Case Reports (which was the first international, Pubmed-listed medical journal publishing only case reports) as the first of this new brand. The climate of skepticism has been replaced by enthusiasm and demand for more case reports. A registry for case reports, Cases Database, was founded in 2012[ 67 ]. On the condition that it succeeds in becoming a large, international database it could serve as a register being useful for clinicians at work as well as for medical research on various clinical issues. Assuming Pamela P. Powell’s assertion that “[a]lmost all practicing physicians eventually will encounter a case worthy of being reported”[ 60 ] is valid, there should be no shortage of potential cases waiting to be reported and filed in various databases, preferably online and open access.

Limitations of this review

There are several limitations to this study. It is a weakness that we have not been able to review all the relevant literature. The number of publications in some way related to case reports and case report series is enormous, and although we have attempted to identify those publications relevant for our purpose (i.e. those that describe the merits and limitations of the case report genre), we might have missed some. It was difficult to find good search terms for our objective. Still, after repeated electronic searches supplemented with manual searches in reference lists, we had a corpus of literature where essentially no new merits or limitations emerged.

As we point out above, the ranking of merits and limitations represents our subjective opinion and we acknowledge that others might rank the importance of the items differently.

The perspective on merits and limitations of case reporting has been strictly medical. As a consequence we have not analyzed or discussed the various non-medical factors affecting the publication of case reports in different medical journals[ 2 ]. For instance, case reports are cited less often than other kinds of medical research articles[ 68 ]. Thus they can lower a journal’s impact factor, potentially making the journal less attractive. This might lead some high-impact journals to publish few or no case reports, while other journals have chosen to specialize in this genre.

Before deciding on producing a case report or case series based on a particular patient or patients at hand, the observant clinician has to determine if the case report method is the appropriate article type. This review could hopefully assist in that judgment and perhaps be a stimulus to the continuing debate in the medical community on the value of case reporting.

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Nissen, T., Wynn, R. The clinical case report: a review of its merits and limitations. BMC Res Notes 7 , 264 (2014). https://doi.org/10.1186/1756-0500-7-264

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A  case series  is essentially a collection of  case reports  around a common theme. It belongs to the class of descriptive studies .

A case series typically contains:

  • a short introduction
  • patient history, presentation, imaging, and clinical course are described in sequential separate sections (patient 1, patient 2, patient 3...)
  • summary/discussion

The case series has many of the same advantages and disadvantages of the case report.

The presentation of multiple cases lends more weight to an underlying hypothesis (stated or unstated) than does a single case report. The case series has less power in defending a hypothesis than other retrospective or prospective studies , however.

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case series study disadvantages

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Home » Pros and Cons » 12 Case Study Method Advantages and Disadvantages

12 Case Study Method Advantages and Disadvantages

A case study is an investigation into an individual circumstance. The investigation may be of a single person, business, event, or group. The investigation involves collecting in-depth data about the individual entity through the use of several collection methods. Interviews and observation are two of the most common forms of data collection used.

The case study method was originally developed in the field of clinical medicine. It has expanded since to other industries to examine key results, either positive or negative, that were received through a specific set of decisions. This allows for the topic to be researched with great detail, allowing others to glean knowledge from the information presented.

Here are the advantages and disadvantages of using the case study method.

List of the Advantages of the Case Study Method

1. it turns client observations into useable data..

Case studies offer verifiable data from direct observations of the individual entity involved. These observations provide information about input processes. It can show the path taken which led to specific results being generated. Those observations make it possible for others, in similar circumstances, to potentially replicate the results discovered by the case study method.

2. It turns opinion into fact.

Case studies provide facts to study because you’re looking at data which was generated in real-time. It is a way for researchers to turn their opinions into information that can be verified as fact because there is a proven path of positive or negative development. Singling out a specific incident also provides in-depth details about the path of development, which gives it extra credibility to the outside observer.

3. It is relevant to all parties involved.

Case studies that are chosen well will be relevant to everyone who is participating in the process. Because there is such a high level of relevance involved, researchers are able to stay actively engaged in the data collection process. Participants are able to further their knowledge growth because there is interest in the outcome of the case study. Most importantly, the case study method essentially forces people to make a decision about the question being studied, then defend their position through the use of facts.

4. It uses a number of different research methodologies.

The case study method involves more than just interviews and direct observation. Case histories from a records database can be used with this method. Questionnaires can be distributed to participants in the entity being studies. Individuals who have kept diaries and journals about the entity being studied can be included. Even certain experimental tasks, such as a memory test, can be part of this research process.

5. It can be done remotely.

Researchers do not need to be present at a specific location or facility to utilize the case study method. Research can be obtained over the phone, through email, and other forms of remote communication. Even interviews can be conducted over the phone. That means this method is good for formative research that is exploratory in nature, even if it must be completed from a remote location.

6. It is inexpensive.

Compared to other methods of research, the case study method is rather inexpensive. The costs associated with this method involve accessing data, which can often be done for free. Even when there are in-person interviews or other on-site duties involved, the costs of reviewing the data are minimal.

7. It is very accessible to readers.

The case study method puts data into a usable format for those who read the data and note its outcome. Although there may be perspectives of the researcher included in the outcome, the goal of this method is to help the reader be able to identify specific concepts to which they also relate. That allows them to discover unusual features within the data, examine outliers that may be present, or draw conclusions from their own experiences.

List of the Disadvantages of the Case Study Method

1. it can have influence factors within the data..

Every person has their own unconscious bias. Although the case study method is designed to limit the influence of this bias by collecting fact-based data, it is the collector of the data who gets to define what is a “fact” and what is not. That means the real-time data being collected may be based on the results the researcher wants to see from the entity instead. By controlling how facts are collected, a research can control the results this method generates.

2. It takes longer to analyze the data.

The information collection process through the case study method takes much longer to collect than other research options. That is because there is an enormous amount of data which must be sifted through. It’s not just the researchers who can influence the outcome in this type of research method. Participants can also influence outcomes by given inaccurate or incomplete answers to questions they are asked. Researchers must verify the information presented to ensure its accuracy, and that takes time to complete.

3. It can be an inefficient process.

Case study methods require the participation of the individuals or entities involved for it to be a successful process. That means the skills of the researcher will help to determine the quality of information that is being received. Some participants may be quiet, unwilling to answer even basic questions about what is being studied. Others may be overly talkative, exploring tangents which have nothing to do with the case study at all. If researchers are unsure of how to manage this process, then incomplete data is often collected.

4. It requires a small sample size to be effective.

The case study method requires a small sample size for it to yield an effective amount of data to be analyzed. If there are different demographics involved with the entity, or there are different needs which must be examined, then the case study method becomes very inefficient.

5. It is a labor-intensive method of data collection.

The case study method requires researchers to have a high level of language skills to be successful with data collection. Researchers must be personally involved in every aspect of collecting the data as well. From reviewing files or entries personally to conducting personal interviews, the concepts and themes of this process are heavily reliant on the amount of work each researcher is willing to put into things.

These case study method advantages and disadvantages offer a look at the effectiveness of this research option. With the right skill set, it can be used as an effective tool to gather rich, detailed information about specific entities. Without the right skill set, the case study method becomes inefficient and inaccurate.

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How to design a good case series

Affiliation.

  • 1 Division of Orthopaedic Surgery, Department of Surgery, McMaster University, 293 Wellington Street North, Suite 110, Hamilton, ON L8L 2X2, Canada.
  • PMID: 19411496
  • DOI: 10.2106/JBJS.H.01573

A case series is a descriptive study that follows a group of patients who have a similar diagnosis or who are undergoing the same procedure over a certain period of time. As there is no experimental protocol or control for allocation of patients to treatment, surgeons and patients decide on whether or not treatment is given, making the clinical sample representative of a common clinical population. Results of case series can generate hypotheses that are useful in designing further studies, including randomized controlled trials. However, no causal inferences should be made from case series regarding the efficacy of the investigated treatment. This article will provide principles for the design, analysis, and reporting of case series, illustrated by examples from the orthopaedic surgical literature.

  • Biomedical Research / methods*
  • Case-Control Studies*
  • Evidence-Based Medicine
  • Observation
  • Orthopedics*
  • Outcome Assessment, Health Care
  • Randomized Controlled Trials as Topic
  • Reproducibility of Results
  • Research Design*

Special Report

Airline and Transportation Bankruptcy Enterprise Values and Creditor Recoveries (2024 Fitch Case Studies)

Thu 22 Feb, 2024 - 12:56 PM ET

In this update to Fitch Ratings’ recurring U.S. corporate bankruptcy case study series, Fitch provides one new case study and republishes 22 cases from prior editions. Disclaimer: Fitch cautions the case studies are not intended to provide exact recovery outcomes, valuations or legal opinions. Estimates in this report may vary significantly from final case outcomes. U.S. airline bankruptcy cases completed a number of years ago were aimed at cost cuts, including pension funding, labor contracts and fleets. Debt reduction was less of a focus in these bankruptcies compared with other sectors. This trend continued with the pandemic-era filers with each of LATAM Airlines Group S.A., Avianca Holdings S.A. and Grupo Aeromexico S.A.B. reducing debt by less than 30%. The median debt reduction was 44% for the airline and transportation cases, compared with 76% in Fitch Ratings’ cross-sector corporate bankruptcy database.

case series study disadvantages

1 in 4 children in New York City are living in poverty, study says

Researchers studied rates of poverty, material hardship and disadvantages.

Poverty in New York City is rising at a startling rate and it's affecting the city's most vulnerable residents -- children, according to a newly released report .

More than half of New York City residents, including a quarter of all children, live in poverty or are low-income, according to the Poverty Tracker Annual Report from Columbia University and the philanthropic organization Robin Hood.

Researchers surveyed a sample of 3,000 New York households for three months to track data on employment, assets, debts and health.

MORE: US poverty rate jumped in 2022, child poverty more than doubled: Census

Overall, the city's poverty rate increased from 18% to 23% and the number of New Yorkers living in poverty grew from 1.5 million to 2 million between 2021 and 2022, marking the largest single-year jump in poverty rates in a decade, according to the report.

The child poverty rate increased 66% from the previous year, according to the report.

Factors that influenced the poverty rate were the end of pandemic-era policies such as the Child Tax Credit and federal stimulus payments, the report noted.

PHOTO: A playground is seen in an undated stock photo.

"A clear path out of poverty requires a stronger safety net— and a policy of real investment in families with universal childcare," Roberto Cordero, executive director of Grand Street Settlement, a nonprofit organization in New York, said in a press release . "One hundred percent of the 18,000 New Yorkers we serve at Grand Street are low income due to low wage jobs, inflation, and the cost of quality childcare and housing."

The report also highlighted the disproportional rate at which minorities are experiencing poverty in relation to white New Yorkers.

Latino residents are twice as likely to live in poverty compared to white residents -- 26% compared to 13%, according to the report.

Researchers said poverty rates for Asian and Black residents increased as well, by 24 and 23%, respectively.

MORE: After-school programs for homeless NYC youth push to make a difference

The report found that women were more likely than men to be unable to afford their basic needs. It's based on a metric called the Supplemental Poverty Measure, or poverty line, which is $43,890 per year. This figure represents what is needed for a NYC household with two adults and two children to afford a minimal basic standard of need.

The poverty threshold for a single adult renter was $20,340 in annual income, according to the report.

Poverty in New York City is nearly twice as high as the national poverty rate, which is 12%.

MORE: Report paints new picture of homelessness in California

This is the sixth comprehensive Poverty Tracker Annual Report since 2012. Researchers monitored the impacts that COVID-19 and the related economic decline have had on New York City residents since the beginning of the pandemic.

"Our city is in the midst of an affordability crisis," Richard R. Buery Jr., CEO of Robin Hood, said in a statement . "This would be deeply troubling at any point, but it is particularly disturbing given the steady progress New York City has made to reduce poverty in years prior."

Buery noted that "temporary, stabilizing government policies" during the COVID-19 pandemic were able to help 500,000 children avoid poverty.

"But we have lacked the will to keep these policies in force," he added. "We know that fully refundable tax credits, housing vouchers, and childcare subsidies can move millions out of poverty and hardship. We are calling on lawmakers to make investments that will help our neighbors live lives of opportunity."

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Single-Case Design, Analysis, and Quality Assessment for Intervention Research

Michele a. lobo.

1 Biomechanics & Movement Science Program, Department of Physical Therapy, University of Delaware, Newark, DE, USA

Mariola Moeyaert

2 Division of Educational Psychology & Methodology, State University of New York at Albany, Albany, NY, USA

Andrea Baraldi Cunha

Iryna babik, background and purpose.

The purpose of this article is to describe single-case studies, and contrast them with case studies and randomized clinical trials. We will highlight current research designs, analysis techniques, and quality appraisal tools relevant for single-case rehabilitation research.

Summary of Key Points

Single-case studies can provide a viable alternative to large group studies such as randomized clinical trials. Single case studies involve repeated measures, and manipulation of and independent variable. They can be designed to have strong internal validity for assessing causal relationships between interventions and outcomes, and external validity for generalizability of results, particularly when the study designs incorporate replication, randomization, and multiple participants. Single case studies should not be confused with case studies/series (ie, case reports), which are reports of clinical management of one patient or a small series of patients.

Recommendations for Clinical Practice

When rigorously designed, single-case studies can be particularly useful experimental designs in a variety of situations, even when researcher resources are limited, studied conditions have low incidences, or when examining effects of novel or expensive interventions. Readers will be directed to examples from the published literature in which these techniques have been discussed, evaluated for quality, and implemented.

Introduction

The purpose of this article is to present current tools and techniques relevant for single-case rehabilitation research. Single-case (SC) studies have been identified by a variety of names, including “n of 1 studies” and “single-subject” studies. The term “single-case study” is preferred over the previously mentioned terms because previous terms suggest these studies include only one participant. In fact, as will be discussed below, for purposes of replication and improved generalizability, the strongest SC studies commonly include more than one participant.

A SC study should not be confused with a “case study/series “ (also called “case report”. In a typical case study/series, a single patient or small series of patients is involved, but there is not a purposeful manipulation of an independent variable, nor are there necessarily repeated measures. Most case studies/series are reported in a narrative way while results of SC studies are presented numerically or graphically. 1 , 2 This article defines SC studies, contrasts them with randomized clinical trials, discusses how they can be used to scientifically test hypotheses, and highlights current research designs, analysis techniques, and quality appraisal tools that may be useful for rehabilitation researchers.

In SC studies, measurements of outcome (dependent variables) are recorded repeatedly for individual participants across time and varying levels of an intervention (independent variables). 1 – 5 These varying levels of intervention are referred to as “phases” with one phase serving as a baseline or comparison, so each participant serves as his/her own control. 2 In contrast to case studies and case series in which participants are observed across time without experimental manipulation of the independent variable, SC studies employ systematic manipulation of the independent variable to allow for hypothesis testing. 1 , 6 As a result, SC studies allow for rigorous experimental evaluation of intervention effects and provide a strong basis for establishing causal inferences. Advances in design and analysis techniques for SC studies observed in recent decades have made SC studies increasingly popular in educational and psychological research. Yet, the authors believe SC studies have been undervalued in rehabilitation research, where randomized clinical trials (RCTs) are typically recommended as the optimal research design to answer questions related to interventions. 7 In reality, there are advantages and disadvantages to both SC studies and RCTs that should be carefully considered in order to select the best design to answer individual research questions. While there are a variety of other research designs that could be utilized in rehabilitation research, only SC studies and RCTs are discussed here because SC studies are the focus of this article and RCTs are the most highly recommended design for intervention studies. 7

When designed and conducted properly, RCTs offer strong evidence that changes in outcomes may be related to provision of an intervention. However, RCTs require monetary, time, and personnel resources that many researchers, especially those in clinical settings, may not have available. 8 RCTs also require access to large numbers of consenting participants that meet strict inclusion and exclusion criteria that can limit variability of the sample and generalizability of results. 9 The requirement for large participant numbers may make RCTs difficult to perform in many settings, such as rural and suburban settings, and for many populations, such as those with diagnoses marked by lower prevalence. 8 To rely exclusively on RCTs has the potential to result in bodies of research that are skewed to address the needs of some individuals while neglecting the needs of others. RCTs aim to include a large number of participants and to use random group assignment to create study groups that are similar to one another in terms of all potential confounding variables, but it is challenging to identify all confounding variables. Finally, the results of RCTs are typically presented in terms of group means and standard deviations that may not represent true performance of any one participant. 10 This can present as a challenge for clinicians aiming to translate and implement these group findings at the level of the individual.

SC studies can provide a scientifically rigorous alternative to RCTs for experimentally determining the effectiveness of interventions. 1 , 2 SC studies can assess a variety of research questions, settings, cases, independent variables, and outcomes. 11 There are many benefits to SC studies that make them appealing for intervention research. SC studies may require fewer resources than RCTs and can be performed in settings and with populations that do not allow for large numbers of participants. 1 , 2 In SC studies, each participant serves as his/her own comparison, thus controlling for many confounding variables that can impact outcome in rehabilitation research, such as gender, age, socioeconomic level, cognition, home environment, and concurrent interventions. 2 , 11 Results can be analyzed and presented to determine whether interventions resulted in changes at the level of the individual, the level at which rehabilitation professionals intervene. 2 , 12 When properly designed and executed, SC studies can demonstrate strong internal validity to determine the likelihood of a causal relationship between the intervention and outcomes and external validity to generalize the findings to broader settings and populations. 2 , 12 , 13

Single Case Research Designs for Intervention Research

There are a variety of SC designs that can be used to study the effectiveness of interventions. Here we discuss: 1) AB designs, 2) reversal designs, 3) multiple baseline designs, and 4) alternating treatment designs, as well as ways replication and randomization techniques can be used to improve internal validity of all of these designs. 1 – 3 , 12 – 14

The simplest of these designs is the AB Design 15 ( Figure 1 ). This design involves repeated measurement of outcome variables throughout a baseline control/comparison phase (A ) and then throughout an intervention phase (B). When possible, it is recommended that a stable level and/or rate of change in performance be observed within the baseline phase before transitioning into the intervention phase. 2 As with all SC designs, it is also recommended that there be a minimum of five data points in each phase. 1 , 2 There is no randomization or replication of the baseline or intervention phases in the basic AB design. 2 Therefore, AB designs have problems with internal validity and generalizability of results. 12 They are weak in establishing causality because changes in outcome variables could be related to a variety of other factors, including maturation, experience, learning, and practice effects. 2 , 12 Sample data from a single case AB study performed to assess the impact of Floor Play intervention on social interaction and communication skills for a child with autism 15 are shown in Figure 1 .

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An example of results from a single-case AB study conducted on one participant with autism; two weeks of observation (baseline phase A) were followed by seven weeks of Floor Time Play (intervention phase B). The outcome measure Circles of Communications (reciprocal communication with two participants responding to each other verbally or nonverbally) served as a behavioral indicator of the child’s social interaction and communication skills (higher scores indicating better performance). A statistically significant improvement in Circles of Communication was found during the intervention phase as compared to the baseline. Note that although a stable baseline is recommended for SC studies, it is not always possible to satisfy this requirement, as you will see in Figures 1 – 4 . Data were extracted from Dionne and Martini (2011) 15 utilizing Rohatgi’s WebPlotDigitizer software. 78

If an intervention does not have carry-over effects, it is recommended to use a Reversal Design . 2 For example, a reversal A 1 BA 2 design 16 ( Figure 2 ) includes alternation of the baseline and intervention phases, whereas a reversal A 1 B 1 A 2 B 2 design 17 ( Figure 3 ) consists of alternation of two baseline (A 1 , A 2 ) and two intervention (B 1 , B 2 ) phases. Incorporating at least four phases in the reversal design (i.e., A 1 B 1 A 2 B 2 or A 1 B 1 A 2 B 2 A 3 B 3 …) allows for a stronger determination of a causal relationship between the intervention and outcome variables, because the relationship can be demonstrated across at least three different points in time – change in outcome from A 1 to B 1 , from B 1 to A 2 , and from A 2 to B 2 . 18 Before using this design, however, researchers must determine that it is safe and ethical to withdraw the intervention, especially in cases where the intervention is effective and necessary. 12

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An example of results from a single-case A 1 BA 2 study conducted on eight participants with stable multiple sclerosis (data on three participants were used for this example). Four weeks of observation (baseline phase A 1 ) were followed by eight weeks of core stability training (intervention phase B), then another four weeks of observation (baseline phase A 2 ). Forward functional reach test (the maximal distance the participant can reach forward or lateral beyond arm’s length, maintaining a fixed base of support in the standing position; higher scores indicating better performance) significantly improved during intervention for Participants 1 and 3 without further improvement observed following withdrawal of the intervention (during baseline phase A 2 ). Data were extracted from Freeman et al. (2010) 16 utilizing Rohatgi’s WebPlotDigitizer software. 78

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An example of results from a single-case A 1 B 1 A 2 B 2 study conducted on two participants with severe unilateral neglect after a right-hemisphere stroke. Two weeks of conventional treatment (baseline phases A 1, A 2 ) alternated with two weeks of visuo-spatio-motor cueing (intervention phases B 1 , B 2 ). Performance was assessed in two tests of lateral neglect, the Bells Cancellation Test (Figure A; lower scores indicating better performance) and the Line Bisection Test (Figure B; higher scores indicating better performance). There was a statistically significant intervention-related improvement in participants’ performance on the Line Bisection Test, but not on the Bells Test. Data were extracted from Samuel at al. (2000) 17 utilizing Rohatgi’s WebPlotDigitizer software. 78

A recent study used an ABA reversal SC study to determine the effectiveness of core stability training in 8 participants with multiple sclerosis. 16 During the first four weekly data collections, the researchers ensured a stable baseline, which was followed by eight weekly intervention data points, and concluded with four weekly withdrawal data points. Intervention significantly improved participants’ walking and reaching performance ( Figure 2 ). 16 This A 1 BA 2 design could have been strengthened by the addition of a second intervention phase for replication (A 1 B 1 A 2 B 2 ). For instance, a single-case A 1 B 1 A 2 B 2 withdrawal design aimed to assess the efficacy of rehabilitation using visuo-spatio-motor cueing for two participants with severe unilateral neglect after a severe right-hemisphere stroke. 17 Each phase included 8 data points. Statistically significant intervention-related improvement was observed, suggesting that visuo-spatio-motor cueing might be promising for treating individuals with very severe neglect ( Figure 3 ). 17

The reversal design can also incorporate a cross over design where each participant experiences more than one type of intervention. For instance, a B 1 C 1 B 2 C 2 design could be used to study the effects of two different interventions (B and C) on outcome measures. Challenges with including more than one intervention involve potential carry-over effects from earlier interventions and order effects that may impact the measured effectiveness of the interventions. 2 , 12 Including multiple participants and randomizing the order of intervention phase presentations are tools to help control for these types of effects. 19

When an intervention permanently changes an individual’s ability, a return to baseline performance is not feasible and reversal designs are not appropriate. Multiple Baseline Designs (MBDs) are useful in these situations ( Figure 4 ). 20 MBDs feature staggered introduction of the intervention across time: each participant is randomly assigned to one of at least 3 experimental conditions characterized by the length of the baseline phase. 21 These studies involve more than one participant, thus functioning as SC studies with replication across participants. Staggered introduction of the intervention allows for separation of intervention effects from those of maturation, experience, learning, and practice. For example, a multiple baseline SC study was used to investigate the effect of an anti-spasticity baclofen medication on stiffness in five adult males with spinal cord injury. 20 The subjects were randomly assigned to receive 5–9 baseline data points with a placebo treatment prior to the initiation of the intervention phase with the medication. Both participants and assessors were blind to the experimental condition. The results suggested that baclofen might not be a universal treatment choice for all individuals with spasticity resulting from a traumatic spinal cord injury ( Figure 4 ). 20

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An example of results from a single-case multiple baseline study conducted on five participants with spasticity due to traumatic spinal cord injury. Total duration of data collection was nine weeks. The first participant was switched from placebo treatment (baseline) to baclofen treatment (intervention) after five data collection sessions, whereas each consecutive participant was switched to baclofen intervention at the subsequent sessions through the ninth session. There was no statistically significant effect of baclofen on viscous stiffness at the ankle joint. Data were extracted from Hinderer at al. (1990) 20 utilizing Rohatgi’s WebPlotDigitizer software. 78

The impact of two or more interventions can also be assessed via Alternating Treatment Designs (ATDs) . In ATDs, after establishing the baseline, the experimenter exposes subjects to different intervention conditions administered in close proximity for equal intervals ( Figure 5 ). 22 ATDs are prone to “carry-over effects” when the effects of one intervention influence the observed outcomes of another intervention. 1 As a result, such designs introduce unique challenges when attempting to determine the effects of any one intervention and have been less commonly utilized in rehabilitation. An ATD was used to monitor disruptive behaviors in the school setting throughout a baseline followed by an alternating treatment phase with randomized presentation of a control condition or an exercise condition. 23 Results showed that 30 minutes of moderate to intense physical activity decreased behavioral disruptions through 90 minutes after the intervention. 23 An ATD was also used to compare the effects of commercially available and custom-made video prompts on the performance of multi-step cooking tasks in four participants with autism. 22 Results showed that participants independently performed more steps with the custom-made video prompts ( Figure 5 ). 22

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An example of results from a single case alternating treatment study conducted on four participants with autism (data on two participants were used for this example). After the observation phase (baseline), effects of commercially available and custom-made video prompts on the performance of multi-step cooking tasks were identified (treatment phase), after which only the best treatment was used (best treatment phase). Custom-made video prompts were most effective for improving participants’ performance of multi-step cooking tasks. Data were extracted from Mechling at al. (2013) 22 utilizing Rohatgi’s WebPlotDigitizer software. 78

Regardless of the SC study design, replication and randomization should be incorporated when possible to improve internal and external validity. 11 The reversal design is an example of replication across study phases. The minimum number of phase replications needed to meet quality standards is three (A 1 B 1 A 2 B 2 ), but having four or more replications is highly recommended (A 1 B 1 A 2 B 2 A 3 …). 11 , 14 In cases when interventions aim to produce lasting changes in participants’ abilities, replication of findings may be demonstrated by replicating intervention effects across multiple participants (as in multiple-participant AB designs), or across multiple settings, tasks, or service providers. When the results of an intervention are replicated across multiple reversals, participants, and/or contexts, there is an increased likelihood a causal relationship exists between the intervention and the outcome. 2 , 12

Randomization should be incorporated in SC studies to improve internal validity and the ability to assess for causal relationships among interventions and outcomes. 11 In contrast to traditional group designs, SC studies often do not have multiple participants or units that can be randomly assigned to different intervention conditions. Instead, in randomized phase-order designs , the sequence of phases is randomized. Simple or block randomization is possible. For example, with simple randomization for an A 1 B 1 A 2 B 2 design, the A and B conditions are treated as separate units and are randomly assigned to be administered for each of the pre-defined data collection points. As a result, any combination of A-B sequences is possible without restrictions on the number of times each condition is administered or regard for repetitions of conditions (e.g., A 1 B 1 B 2 A 2 B 3 B 4 B 5 A 3 B 6 A 4 A 5 A 6 ). With block randomization for an A 1 B 1 A 2 B 2 design, two conditions (e.g., A and B) would be blocked into a single unit (AB or BA), randomization of which to different time periods would ensure that each condition appears in the resulting sequence more than two times (e.g., A 1 B 1 B 2 A 2 A 3 B 3 A 4 B 4 ). Note that AB and reversal designs require that the baseline (A) always precedes the first intervention (B), which should be accounted for in the randomization scheme. 2 , 11

In randomized phase start-point designs , the lengths of the A and B phases can be randomized. 2 , 11 , 24 – 26 For example, for an AB design, researchers could specify the number of time points at which outcome data will be collected, (e.g., 20), define the minimum number of data points desired in each phase (e.g., 4 for A, 3 for B), and then randomize the initiation of the intervention so that it occurs anywhere between the remaining time points (points 5 and 17 in the current example). 27 , 28 For multiple-baseline designs, a dual-randomization, or “regulated randomization” procedure has been recommended. 29 If multiple-baseline randomization depends solely on chance, it could be the case that all units are assigned to begin intervention at points not really separated in time. 30 Such randomly selected initiation of the intervention would result in the drastic reduction of the discriminant and internal validity of the study. 29 To eliminate this issue, investigators should first specify appropriate intervals between the start points for different units, then randomly select from those intervals, and finally randomly assign each unit to a start point. 29

Single Case Analysis Techniques for Intervention Research

The What Works Clearinghouse (WWC) single-case design technical documentation provides an excellent overview of appropriate SC study analysis techniques to evaluate the effectiveness of intervention effects. 1 , 18 First, visual analyses are recommended to determine whether there is a functional relation between the intervention and the outcome. Second, if evidence for a functional effect is present, the visual analysis is supplemented with quantitative analysis methods evaluating the magnitude of the intervention effect. Third, effect sizes are combined across cases to estimate overall average intervention effects which contributes to evidence-based practice, theory, and future applications. 2 , 18

Visual Analysis

Traditionally, SC study data are presented graphically. When more than one participant engages in a study, a spaghetti plot showing all of their data in the same figure can be helpful for visualization. Visual analysis of graphed data has been the traditional method for evaluating treatment effects in SC research. 1 , 12 , 31 , 32 The visual analysis involves evaluating level, trend, and stability of the data within each phase (i.e., within-phase data examination) followed by examination of the immediacy of effect, consistency of data patterns, and overlap of data between baseline and intervention phases (i.e., between-phase comparisons). When the changes (and/or variability) in level are in the desired direction, are immediate, readily discernible, and maintained over time, it is concluded that the changes in behavior across phases result from the implemented treatment and are indicative of improvement. 33 Three demonstrations of an intervention effect are necessary for establishing a functional relation. 1

Within-phase examination

Level, trend, and stability of the data within each phase are evaluated. Mean and/or median can be used to report the level, and trend can be evaluated by determining whether the data points are monotonically increasing or decreasing. Within-phase stability can be evaluated by calculating the percentage of data points within 15% of the phase median (or mean). The stability criterion is satisfied if about 85% (80% – 90%) of the data in a phase fall within a 15% range of the median (or average) of all data points for that phase. 34

Between-phase examination

Immediacy of effect, consistency of data patterns, and overlap of data between baseline and intervention phases are evaluated next. For this, several nonoverlap indices have been proposed that all quantify the proportion of measurements in the intervention phase not overlapping with the baseline measurements. 35 Nonoverlap statistics are typically scaled as percent from 0 to 100, or as a proportion from 0 to 1. Here, we briefly discuss the Nonoverlap of All Pairs ( NAP ), 36 the Extended Celeration Line ( ECL ), the Improvement Rate Difference ( IRD) , 37 and the TauU and the TauU-adjusted, TauU adj , 35 as these are the most recent and complete techniques. We also examine the Percentage of Nonoverlapping Data ( PND ) 38 and the Two Standard Deviations Band Method, as these are frequently used techniques. In addition, we include the Percentage of Nonoverlapping Corrected Data ( PNCD ) – an index applying to the PND after controlling for baseline trend. 39

Nonoverlap of all pairs (NAP)

Each baseline observation can be paired with each intervention phase observation to make n pairs (i.e., N = n A * n B ). Count the number of overlapping pairs, n o , counting all ties as 0.5. Then define the percent of the pairs that show no overlap. Alternatively, one can count the number of positive (P), negative (N), and tied (T) pairs 2 , 36 :

Extended Celeration Line (ECL)

ECL or split middle line allows control for a positive Phase A trend. Nonoverlap is defined as the proportion of Phase B ( n b ) data that are above the median trend plotted from Phase A data ( n B< sub > Above Median trend A </ sub > ), but then extended into Phase B: ECL = n B Above Median trend A n b ∗ 100

As a consequence, this method depends on a straight line and makes an assumption of linearity in the baseline. 2 , 12

Improvement rate difference (IRD)

This analysis is conceptualized as the difference in improvement rates (IR) between baseline ( IR B ) and intervention phases ( IR T ). 38 The IR for each phase is defined as the number of “improved data points” divided by the total data points in that phase. IRD, commonly employed in medical group research under the name of “risk reduction” or “risk difference” attempts to provide an intuitive interpretation for nonoverlap and to make use of an established, respected effect size, IR B - IR B , or the difference between two proportions. 37

TauU and TauU adj

Each baseline observation can be paired with each intervention phase observation to make n pairs (i.e., n = n A * n B ). Count the number of positive (P), negative (N), and tied (T) pairs, and use the following formula: TauU = P - N P + N + τ

The TauU adj is an adjustment of TauU for monotonic trend in baseline. Each baseline observation can be paired with each intervention phase observation to make n pairs (i.e., n = n A * n B ). Each baseline observation can be paired with all later baseline observations (n A *(n A -1)/2). 2 , 35 Then the baseline trend can be computed: TauU adf = P - N - S trend P + N + τ ; S trend = P A – NA

Online calculators might assist researchers in obtaining the TauU and TauU adjusted coefficients ( http://www.singlecaseresearch.org/calculators/tau-u ).

Percentage of nonoverlapping data (PND)

If anticipating an increase in the outcome, locate the highest data point in the baseline phase and then calculate the percent of the intervention phase data points that exceed it. If anticipating a decrease in the outcome, find the lowest data point in the baseline phase and then calculate the percent of the treatment phase data points that are below it: PND = n B Overlap A n b ∗ 100 . A PND < 50 would mark no observed effect, PND = 50–70 signifies a questionable effect, and PND > 70 suggests the intervention was effective. 40 The percentage of nonoverlapping (PNDC) corrected was proposed in 2009 as an extension of the PND. 39 Prior to applying the PND, a data correction procedure is applied eliminating pre-existing baseline trend. 38

Two Standard Deviation Band Method

When the stability criterion described above is met within phases, it is possible to apply the two standard deviation band method. 12 , 41 First, the mean of the data for a specific condition is calculated and represented with a solid line. In the next step, the standard deviation of the same data is computed and two dashed lines are represented: one located two standard deviations above the mean and the other – two standard deviations below. For normally distributed data, few points (less than 5%) are expected to be outside the two standard deviation bands if there is no change in the outcome score due to the intervention. However, this method is not considered a formal statistical procedure, as the data cannot typically be assumed to be normal, continuous, or independent. 41

Statistical Analysis

If the visual analysis indicates a functional relationship (i.e., three demonstrations of the effectiveness of the intervention effect), it is recommended to proceed with the quantitative analyses, reflecting the magnitude of the intervention effect. First, effect sizes are calculated for each participant (individual-level analysis). Moreover, if the research interest lies in the generalizability of the effect size across participants, effect sizes can be combined across cases to achieve an overall average effect size estimate (across-case effect size).

Note that quantitative analysis methods are still being developed in the domain of SC research 1 and statistical challenges of producing an acceptable measure of treatment effect remain. 14 , 42 , 43 Therefore, the WWC standards strongly recommend conducting sensitivity analysis and reporting multiple effect size estimators. If consistency across different effect size estimators is identified, there is stronger evidence for the effectiveness of the treatment. 1 , 18

Individual-level effect size analysis

The most common effect sizes recommended for SC analysis are: 1) standardized mean difference Cohen’s d ; 2) standardized mean difference with correction for small sample sizes Hedges’ g ; and 3) the regression-based approach which has the most potential and is strongly recommended by the WWC standards. 1 , 44 , 45 Cohen’s d can be calculated using following formula: d = X A ¯ - X B ¯ s p , with X A ¯ being the baseline mean, X B ¯ being the treatment mean, and s p indicating the pooled within-case standard deviation. Hedges’ g is an extension of Cohen’s d , recommended in the context of SC studies as it corrects for small sample sizes. The piecewise regression-based approach does not only reflect the immediate intervention effect, but also the intervention effect across time:

i stands for the measurement occasion ( i = 0, 1,… I ). The dependent variable is regressed on a time indicator, T , which is centered around the first observation of the intervention phase, D , a dummy variable for the intervention phase, and an interaction term of these variables. The equation shows that the expected score, Ŷ i , equals β 0 + β 1 T i in the baseline phase, and ( β 0 + β 2 ) + ( β 1 + β 3 ) T i in the intervention phase. β 0 , therefore, indicates the expected baseline level at the start of the intervention phase (when T = 0), whereas β 1 marks the linear time trend in the baseline scores. The coefficient β 2 can then be interpreted as an immediate effect of the intervention on the outcome, whereas β 3 signifies the effect of the intervention across time. The e i ’s are residuals assumed to be normally distributed around a mean of zero with a variance of σ e 2 . The assumption of independence of errors is usually not met in the context of SC studies because repeated measures are obtained within a person. As a consequence, it can be the case that the residuals are autocorrelated, meaning that errors closer in time are more related to each other compared to errors further away in time. 46 – 48 As a consequence, a lag-1 autocorrelation is appropriate (taking into account the correlation between two consecutive errors: e i and e i –1 ; for more details see Verbeke & Molenberghs, (2000). 49 In Equation 1 , ρ indicates the autocorrelation parameter. If ρ is positive, the errors closer in time are more similar; if ρ is negative, the errors closer in time are more different, and if ρ equals zero, there is no correlation between the errors.

Across-case effect sizes

Two-level modeling to estimate the intervention effects across cases can be used to evaluate across-case effect sizes. 44 , 45 , 50 Multilevel modeling is recommended by the WWC standards because it takes the hierarchical nature of SC studies into account: measurements are nested within cases and cases, in turn, are nested within studies. By conducting a multilevel analysis, important research questions can be addressed (which cannot be answered by single-level analysis of SC study data), such as: 1) What is the magnitude of the average treatment effect across cases? 2) What is the magnitude and direction of the case-specific intervention effect? 3) How much does the treatment effect vary within cases and across cases? 4) Does a case and/or study level predictor influence the treatment’s effect? The two-level model has been validated in previous research using extensive simulation studies. 45 , 46 , 51 The two-level model appears to have sufficient power (> .80) to detect large treatment effects in at least six participants with six measurements. 21

Furthermore, to estimate the across-case effect sizes, the HPS (Hedges, Pustejovsky, and Shadish) , or single-case educational design ( SCEdD)-specific mean difference, index can be calculated. 52 This is a standardized mean difference index specifically designed for SCEdD data, with the aim of making it comparable to Cohen’s d of group-comparison designs. The standard deviation takes into account both within-participant and between-participant variability, and is typically used to get an across-case estimator for a standardized change in level. The advantage of using the HPS across-case effect size estimator is that it is directly comparable with Cohen’s d for group comparison research, thus enabling the use of Cohen’s (1988) benchmarks. 53

Valuable recommendations on SC data analyses have recently been provided. 54 , 55 They suggest that a specific SC study data analytic technique can be chosen based on: (1) the study aims and the desired quantification (e.g., overall quantification, between-phase quantifications, randomization, etc.), (2) the data characteristics as assessed by visual inspection and the assumptions one is willing to make about the data, and (3) the knowledge and computational resources. 54 , 55 Table 1 lists recommended readings and some commonly used resources related to the design and analysis of single-case studies.

Recommend readings and resources related to the design and analysis of single-case studies.

Quality Appraisal Tools for Single-Case Design Research

Quality appraisal tools are important to guide researchers in designing strong experiments and conducting high-quality systematic reviews of the literature. Unfortunately, quality assessment tools for SC studies are relatively novel, ratings across tools demonstrate variability, and there is currently no “gold standard” tool. 56 Table 2 lists important SC study quality appraisal criteria compiled from the most common scales; when planning studies or reviewing the literature, we recommend readers consider these criteria. Table 3 lists some commonly used SC quality assessment and reporting tools and references to resources where the tools can be located.

Summary of important single-case study quality appraisal criteria.

Quality assessment and reporting tools related to single-case studies.

When an established tool is required for systematic review, we recommend use of the What Works Clearinghouse (WWC) Tool because it has well-defined criteria and is developed and supported by leading experts in the SC research field in association with the Institute of Education Sciences. 18 The WWC documentation provides clear standards and procedures to evaluate the quality of SC research; it assesses the internal validity of SC studies, classifying them as “Meeting Standards”, “Meeting Standards with Reservations”, or “Not Meeting Standards”. 1 , 18 Only studies classified in the first two categories are recommended for further visual analysis. Also, WWC evaluates the evidence of effect, classifying studies into “Strong Evidence of a Causal Relation”, “Moderate Evidence of a Causal Relation”, or “No Evidence of a Causal Relation”. Effect size should only be calculated for studies providing strong or moderate evidence of a causal relation.

The Single-Case Reporting Guideline In BEhavioural Interventions (SCRIBE) 2016 is another useful SC research tool developed recently to improve the quality of single-case designs. 57 SCRIBE consists of a 26-item checklist that researchers need to address while reporting the results of SC studies. This practical checklist allows for critical evaluation of SC studies during study planning, manuscript preparation, and review.

Single-case studies can be designed and analyzed in a rigorous manner that allows researchers strength in assessing causal relationships among interventions and outcomes, and in generalizing their results. 2 , 12 These studies can be strengthened via incorporating replication of findings across multiple study phases, participants, settings, or contexts, and by using randomization of conditions or phase lengths. 11 There are a variety of tools that can allow researchers to objectively analyze findings from SC studies. 56 While a variety of quality assessment tools exist for SC studies, they can be difficult to locate and utilize without experience, and different tools can provide variable results. The WWC quality assessment tool is recommended for those aiming to systematically review SC studies. 1 , 18

SC studies, like all types of study designs, have a variety of limitations. First, it can be challenging to collect at least five data points in a given study phase. This may be especially true when traveling for data collection is difficult for participants, or during the baseline phase when delaying intervention may not be safe or ethical. Power in SC studies is related to the number of data points gathered for each participant so it is important to avoid having a limited number of data points. 12 , 58 Second, SC studies are not always designed in a rigorous manner and, thus, may have poor internal validity. This limitation can be overcome by addressing key characteristics that strengthen SC designs ( Table 2 ). 1 , 14 , 18 Third, SC studies may have poor generalizability. This limitation can be overcome by including a greater number of participants, or units. Fourth, SC studies may require consultation from expert methodologists and statisticians to ensure proper study design and data analysis, especially to manage issues like autocorrelation and variability of data. 2 Fifth, while it is recommended to achieve a stable level and rate of performance throughout the baseline, human performance is quite variable and can make this requirement challenging. Finally, the most important validity threat to SC studies is maturation. This challenge must be considered during the design process in order to strengthen SC studies. 1 , 2 , 12 , 58

SC studies can be particularly useful for rehabilitation research. They allow researchers to closely track and report change at the level of the individual. They may require fewer resources and, thus, can allow for high-quality experimental research, even in clinical settings. Furthermore, they provide a tool for assessing causal relationships in populations and settings where large numbers of participants are not accessible. For all of these reasons, SC studies can serve as an effective method for assessing the impact of interventions.

Acknowledgments

This research was supported by the National Institute of Health, Eunice Kennedy Shriver National Institute of Child Health & Human Development (1R21HD076092-01A1, Lobo PI) and the Delaware Economic Development Office (Grant #109).

Some of the information in this manuscript was presented at the IV Step Meeting in Columbus, OH, June 2016.

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  1. case study research advantages and disadvantages

    case series study disadvantages

  2. 2. Case study and case series

    case series study disadvantages

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    case series study disadvantages

  4. advantages and disadvantages of case study ppt 1

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  6. Case Study: Types, Advantages And Disadvantages

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VIDEO

  1. Critical Reasoning Questions

  2. Case Studies

  3. Case Studies

  4. Case Studies

  5. CASE STUDY COM165 VIDEO PRESENTATION

  6. Case study practical

COMMENTS

  1. Case series: design, measures, and classic example

    1. Case series fall below case-control and cohort studies on the hierarchy of study designs. 2. Case series have very detailed clinical information however do not include analysis or draw comparisons to other published studies. 3.

  2. Case Reports, Case Series

    Editorial. Introduction. Case reports and case series or case study research are descriptive studies to present patients in their natural clinical setting. Case reports, which generally consist of three or fewer patients, are prepared to illustrate features in the practice of medicine and potentially create new research questions that may contribute to the acquisition of additional knowledge ...

  3. Three-minute critical appraisal of a case series article

    Case series represents an observational study that reports on data from a subject group without a comparison population. 1 In the hierarchy of evidence, it represents level IV evidence. 2, 3 This is due to lack of control subjects, making case series prone to bias.

  4. The clinical case report: a review of its merits and limitations

    The major limitations were: Lack of ability to generalize, no possibility to establish cause-effect relationship, danger of over-interpretation, publication bias, retrospective design, and distraction of reader when focusing on the unusual. Conclusions

  5. Methodological quality of case series studies: an introducti ...

    Dekkers et al. 8 define a case series as a study in which "only patients with the outcome are sampled (either those who have an exposure or those who are selected without regard to exposure), which does not permit calculation of an absolute risk." (p.39) The outcome could be a disease or disease-related.

  6. Case series: Design, measures, and classic example

    Limitations of case studies include susceptibility to bias, the potential for incomplete patient data, and the absence of a comparison group. Numerous examples of case series exist within the interventional radiology literature and provide examples for investigators seeking to perform their own case series studies. in book Next in book Keywords

  7. Writing Case Reports and Series: Tricks, Traps, and Triumphs ...

    This review article shows the particular advantages and disadvantages of employing this study design and presents a framework to write high-quality case reports and case series. ... Barker TH, Moola S, Tufanaru C, Stern C, McArthur A, et al Methodological quality of case series studies: An introduction to the JBI critical appraisal tool JBI ...

  8. (PDF) What is case series?

    What is case series? Authors: Abdel-Hady El-Gilany Mansoura University Abstract This is the second part of a series on case reports and case series studies. It will help junior...

  9. Case Report

    Lancet. 2 (8247),598-600. This case report was published by eight physicians in New York city who had unexpectedly seen eight male patients with Kaposi's sarcoma (KS). Prior to this, KS was very rare in the U.S. and occurred primarily in the lower extremities of older patients. These cases were decades younger, had generalized KS, and a much ...

  10. Case Studies/ Case Report/ Case Series

    What are the pitfalls to look for? One pitfall that has occurred in some case studies is where two common conditions/treatments have been linked together with no comprehensive data backing up the conclusion.

  11. Case series

    Case series are especially vulnerable to selection bias; for example, studies that report on a series of patients with a certain illness and/or a suspected linked exposure draw their patients from a particular population (such as a hospital or clinic) which may not appropriately represent the wider population.

  12. Study designs: Part 2

    A case series is similar, except that it is an aggregation of multiple (often only a few) similar cases. Many case reports and case series are anecdotal and of limited value. ... DISADVANTAGES. As with other study designs, descriptive studies have their own pitfalls. Case reports and case-series refer to a solitary patient or to only a few ...

  13. The clinical case report: a review of its merits and limitations

    The major limitations were: Lack of ability to generalize, no possibility to establish cause-effect relationship, danger of over-interpretation, publication bias, retrospective design, and distraction of reader when focusing on the unusual. Conclusions

  14. PDF Retrospective Studies and Chart Reviews

    retrospective study uses existing data that have been recorded for reasons other than research. In health care these are often called "chart reviews" because the data source is the medical record. Figure 1 contrasts retrospec-tive and prospective studies. There are 3 general types of retrospective study: case report, case series, and case ...

  15. Case Study Methodology of Qualitative Research: Key Attributes and

    This article attempts to look into the various dimensions of a case study research strategy, the different epistemological strands which determine the particular case study type and approach adopted in the field, discusses the factors which can enhance the effectiveness of a case study research, and the debate surrounding the role of a case stud...

  16. (PDF) Case report and case series

    Descriptive studies are observational studies which range from the case and case series report to extensive epidemiological studies. The essential features of the descriptive studies are its cross ...

  17. Case series

    The case series has many of the same advantages and disadvantages of the case report. The presentation of multiple cases lends more weight to an underlying hypothesis (stated or unstated) than does a single case report. The case series has less power in defending a hypothesis than other retrospective or prospective studies, however ...

  18. 12 Case Study Method Advantages and Disadvantages

    Here are the advantages and disadvantages of using the case study method. List of the Advantages of the Case Study Method 1. It turns client observations into useable data. Case studies offer verifiable data from direct observations of the individual entity involved. These observations provide information about input processes.

  19. How to design a good case series

    A case series is a descriptive study that follows a group of patients who have a similar diagnosis or who are undergoing the same procedure over a certain period of time. As there is no experimental protocol or control for allocation of patients to treatment, surgeons and patients decide on whether …

  20. Case series: an essential study design to build knowledge and pose

    Therefore, a case series differs from cohort studies because the latter compares the risk between two groups (exposed and unexposed) and allows for the estimation of an absolute risk for the occurrence of a given outcome in the exposed group and of a relative risk in comparison with the unexposed group.

  21. 2. Case study and case series

    Case series exist in 2 types: 1. Sampling is based on a specific outcome and presence of a specific exposure. Cases are selected on the basis of a striking association between exposure and outcome. This type of case series can be formally thought of as describing 1 cell (the exposed cases) in an epidemiologic 2 x 2 table.

  22. Airline and Transportation Bankruptcy Enterprise Values and Creditor

    Airline and Transportation Bankruptcy Enterprise Values and Creditor Recoveries (2024 Fitch Case Studies) Thu 22 Feb, 2024 - 12:56 PM ET In this update to Fitch Ratings' recurring U.S. corporate bankruptcy case study series, Fitch provides one new case study and republishes 22 cases from prior editions.

  23. Clarifying the distinction between case series and cohort studies in

    Distinguishing cohort studies from case series is difficult. We propose a conceptualization of cohort studies in systematic reviews of comparative studies. The main aim of this conceptualization is to clarify the distinction between cohort studies and case series.

  24. Gender Pay Gap Persists And Women Are Taxed For Remote Work, Study Finds

    It stands at 87 cents when they enter the workforce but reaches, on average, 82 cents by the time a woman is 30 to 40 years old, and 74 cents by the time she is 45. According to the data, the pay ...

  25. 1 in 4 children in New York City are living in poverty, study says

    Overall, the city's poverty rate increased from 18% to 23% and the number of New Yorkers living in poverty grew from 1.5 million to 2 million between 2021 and 2022, marking the largest single-year ...

  26. Single-Case Design, Analysis, and Quality Assessment for Intervention

    Recommendations for Clinical Practice When rigorously designed, single-case studies can be particularly useful experimental designs in a variety of situations, even when researcher resources are limited, studied conditions have low incidences, or when examining effects of novel or expensive interventions.